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Southampton hand a Premier League debut to 19-year-old French left-back Yan Valery. There’s also a first Premier League start for striker Michael Obafemi.
Manchester United make five changes to the side that stuttered against Young Boys on Tuesday. Chris Smalling, Jesse Lingard, Anthony Martial, Luis Valencia and Fred make way for Scott McTominay, Ander Herrera, Paul Pogba, Romelu Lukaku and Ashley Young.
Southampton: McCarthy, Yoshida, Vestergaard, Stephens, Valery, Hojbjerg, Lemina, Armstrong, Cedric, Redmond, Obafemi.
Subs: Hoedt, Davis, Austin, Romeu, Ward-Prowse, Gabbiadini, Gunn.
Manchester United: de Gea, Young, McTominay, Jones, Shaw, Matic, Herrera, Fellaini, Pogba, Lukaku, Rashford.
Subs: Mata, Martial, Lingard, Rojo, Fred, Dalot, Romero.